Polysaccharide-containing conjugate vaccines for fungal diseases.

Immunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines

Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multir...

Conjugate and Polysaccharide Vaccines Conjugate and Polysaccharide Vaccines, Plenary Review Meningococcal polysaccharide-protein conjugate vaccines

Meningococcal vaccines: past, present, and future perspectives

Meningococcal disease remains a significant global public health issue and is unique among causes of bacterial meningitis and sepsis where not only does it cause sporadic disease but also outbreaks. The prevention of meningococcal disease also presents a serious challenge . Although polysaccharide vaccines have been available for serogroup A, C, Y, and W135 for many years, serogroup C polysacch...

Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: results from a randomized trial.

Adults (n = 282) were randomized to receive either a pneumococcal glycoprotein conjugate vaccine, composed of pneumococcal serotypes 6B, 14, 18C, 19F, and 23F linked to CRM197, or a 23-valent pneumococcal polysaccharide vaccine. Among human immunodeficiency virus (HIV)-uninfected persons, conjugate vaccine elicited significantly higher IgG antibody geometric mean titers (GMTs) than did polysacc...

Increased Invasive Pneumococcal Disease, North East England, UK

Since April 2014, invasive pneumococcal disease incidence has increased substantially across North East England, United Kingdom, reversing the decline that followed the 2006 introduction of pneumococcal conjugate vaccines. Significant increases occurred in 23-valent polysaccharide vaccine serotypes and nonvaccine serotypes. Trends in other regions and long-term effects of multivalent vaccines r...